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Advances in Perinatal Medicine: Volume 5 by Valerie Charlton (auth.), Aubrey Milunsky MB.B.Ch., D.Sc.,

By Valerie Charlton (auth.), Aubrey Milunsky MB.B.Ch., D.Sc., F.R.C.P., D.C.H., Emanuel A. Friedman M.D., Sc.D., Louis Gluck M.D. (eds.)

The country of future health care is mirrored by way of perinatal and neonatal morbidity and mortality in addition to via the frequencies of long term neurologic and developmental issues. Many components, a few with no instantly rec­ ognizable value to childbearing and lots of nonetheless unknown, undoubt­ edly give a contribution beneficially or adversely to the result of being pregnant. wisdom about the effect of such elements at the fetus and sur­ viving baby is important. Confounding analyses of being pregnant end result, specially those previous or 3 a long time, are the results of newly un­ dertaken invasive or inactive healing methods coupled with the appearance of excessive expertise. many inventions were brought with­ out critical efforts to guage their influence prospectively and objectively. the results of healing misadventures characterised the prior; it kind of feels they've been changed to some extent through a number of the issues of utilized know-how. Examples abound: after overuse of oxygen used to be famous to reason retrolental fibroplasia, its restrict ended in an in­ crease in either neonatal loss of life charges and neurologic harm in surviving babies. management of diet okay to avoid neonatal hemorrhagic illness, quite while given in what we now understand as over the top dos­ age, sometimes ended in kernicterus. Prophylactic sulfonamide use had an identical consequence. more moderen is the statement of bronchopul­ monary dysplasia as a trouble of respirator remedy for hyaline membrane disease.

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1981, Maternal nutrition and fetal growth. ]. Clin. Nutr. 34(suppl):769. 6. ]. Obstet. G),necol. 142:670. 7. , 1982, Abilities of children who were small for gestational age babies, Pediatrics 69:296. 8. , 1972, The small for date infant. I. Later growth patterns, Pediatrics 49:671. 36 Valerie CharIton 9. , 1984, Developmental outcome and followup of the small for gestational age infant, Semin. Perinatol. 8: 123. 10. , 1972, The small for date infant. II. Neurological and intellectual sequelae, Pediatrics 50:50.

Rats born to malnourished mothers have a reduction in overall brain weight and DNA content that is more marked in the cerebellum than in the cerebrum. I 10 DNA content is an indicator of tissue cellularity, and microscopic examination of the cerebellum shows a 44% decrease in glial cells and 13% decrease in neurons. 110 Rat pups born to mothers fed a 5% protein and low-calorie diet have a 50% decrease in body size and up to 40% reduction in brain weight. II I Glial cell number is reduced by 50% in the corpus callosum and in ascending spinal sensory tracts.

93 Blood flow per kilogram of fetal weight was decreased in the embolization model 92 but was the same for growth-retarded and control animals in the other preparations measured. 93 ,95 Table IV. Umbilical Blood Flow and Uptake Measurements in Control and Intrauterine Growth-Retarded Fetal Lambsa-e Substrate: rUGR model studied Control fetuses Umbilical flow Spontaneous Dietary restriction Placental embolization Placental embolization Umbilical artery ligation 571 637 641 717 735 Glucose uptake Spontaneous!

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