Press "Enter" to skip to content

Aging Mechanisms: Longevity, Metabolism, and Brain Aging by Nozomu Mori, Inhee Mook-Jung

By Nozomu Mori, Inhee Mook-Jung

This e-book brings jointly the main updated info on fresh learn result of prime laboratories on getting older technology in East Asia, quite in Japan, Korea, and Hong Kong. beginning with a accomplished evaluate of assorted hypotheses on organic mechanisms of getting older via Dr. Sataro Goto, every one bankruptcy covers huge elements of the latest findings in aging-related issues: centenarian experiences and genome research of progeria, metabolic biochemistry and neurobiology, toughness controls in yeast and nematodes, oxidative pressure and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with extra capability healing ways to those age-related neurodegenerative ailments. additionally integrated, partially, is a precis and the results of a systematic dialogue discussion board referred to as the Asian getting older center for sturdiness (AACL) that has been held each year alternating among Japan and Korea over the last decade. This publication can function an invaluable source for locating acceptable collaborators within the components it covers. the objective readership is made from graduate scholars and researchers at universities, clinical and/or life-science colleges, and biomedical and pharmaceutical institutes.

Why does getting older exist? How can we age? How is each one organism’s lifespan decided? those are basic questions within the box. We could be nonetheless faraway from attaining a whole view of getting older mechanisms, yet this ebook, Aging Mechanisms, deals a very good chance to familiarize yourself with the main up to date growth within the biomedical examine of getting older in Japan and Korea, the 2 top countries for human longevity.

Show description

Read Online or Download Aging Mechanisms: Longevity, Metabolism, and Brain Aging PDF

Similar geriatrics books

Geriatrics (Health and Medical Issues Today)

Based on the U. S. Census Bureau, the speed of progress of the aged population—defined as members age sixty five or greater—increased by way of an element of eleven long ago century, from three million in 1900 to 33 million in 1994. throughout the comparable period of time, the full inhabitants purely tripled. by means of the 12 months 2030, there'll be approximately seventy two million older individuals, or approximately 1 in five one of the American population—more than two times their quantity in 2000.

Biological Basis of Geriatric Oncology

Organic foundation of Geriatric Oncology highlights study matters which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and therapy, in response to the biologic interactions of melanoma and age. It illustrates the good thing about the rules of geriatrics within the administration of melanoma within the older person.

Perioperative Medicine: Medical Consultation and Co-management

Presents a accomplished evidence-based consultant to the administration of the becoming inhabitants of sufferers who require perioperative carePerioperative medication: clinical session and Co-Management is the 1st entire reference textual content built in particular for hospitalists yet estimated additionally to assist internists, anesthesiologists, allied well-being execs, fellows, citizens, and scientific scholars deal with a variety of facets of the treatment of the surgical sufferer.

Musculoskeletal Trauma in the Elderly

Trauma in older humans elderly over sixty five is a speedily transforming into box inside orthopaedics. as much as thirds of fractures take place due to a fall and approximately one 3rd of all fractures take place within the over-65 inhabitants. the purpose of this complete new textual content is to provide the epidemiology and administration of all musculoskeletal trauma that happens within the aged.

Additional info for Aging Mechanisms: Longevity, Metabolism, and Brain Aging

Example text

1). Although there appear to be conserved pathways that potentially drive aging (Kenyon 2010), it is not known how these very basic molecular mechanisms result in such great lifespan variation. This has remained an unsolved problem in gerontology. The leading theories that have so far been proposed are apparently acceptable, but not without objections, and different theories interrelate with each other by one theory being a part of the others, suggesting that each one contributes partly to be integrated into explaining the whole process of aging.

Aging (Albany NY) 4:350–358 Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR (2002) Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res 500:135–145 Calabrese EJ, Mattson MP (2011) Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal 5:25–38 Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527–605 Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome.

It has been reported that a worsening frailty status, as measured by the loss of body weight, the development of sarcopenia and muscle weakness, and the reduction in physical activity, is associated with decreased global DNA methylation in the peripheral blood cells of individuals aged 65–105 over a 7-year-follow-up period (Bellizzi et al. 2012). Aging is often associated with reduced levels of global DNA methylation, mostly in CpG sequences, but its physiological implications remain unclear. However, it is known that the age-related hypermethylation of the promoter regions of tumor suppressor genes increase the risk of carcinogenesis.

Download PDF sample

Rated 4.35 of 5 – based on 14 votes