By Nozomu Mori, Inhee Mook-Jung
This e-book brings jointly the main updated info on fresh learn result of prime laboratories on getting older technology in East Asia, quite in Japan, Korea, and Hong Kong. beginning with a accomplished evaluate of assorted hypotheses on organic mechanisms of getting older via Dr. Sataro Goto, every one bankruptcy covers huge elements of the latest findings in aging-related issues: centenarian experiences and genome research of progeria, metabolic biochemistry and neurobiology, toughness controls in yeast and nematodes, oxidative pressure and calorie restrict, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with extra capability healing ways to those age-related neurodegenerative ailments. additionally integrated, partially, is a precis and the results of a systematic dialogue discussion board referred to as the Asian getting older center for sturdiness (AACL) that has been held each year alternating among Japan and Korea over the last decade. This publication can function an invaluable source for locating acceptable collaborators within the components it covers. the objective readership is made from graduate scholars and researchers at universities, clinical and/or life-science colleges, and biomedical and pharmaceutical institutes.
Why does getting older exist? How can we age? How is each one organism’s lifespan decided? those are basic questions within the box. We could be nonetheless faraway from attaining a whole view of getting older mechanisms, yet this ebook, Aging Mechanisms, deals a very good chance to familiarize yourself with the main up to date growth within the biomedical examine of getting older in Japan and Korea, the 2 top countries for human longevity.
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Additional info for Aging Mechanisms: Longevity, Metabolism, and Brain Aging
1). Although there appear to be conserved pathways that potentially drive aging (Kenyon 2010), it is not known how these very basic molecular mechanisms result in such great lifespan variation. This has remained an unsolved problem in gerontology. The leading theories that have so far been proposed are apparently acceptable, but not without objections, and different theories interrelate with each other by one theory being a part of the others, suggesting that each one contributes partly to be integrated into explaining the whole process of aging.
Aging (Albany NY) 4:350–358 Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR (2002) Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res 500:135–145 Calabrese EJ, Mattson MP (2011) Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal 5:25–38 Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527–605 Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome.
It has been reported that a worsening frailty status, as measured by the loss of body weight, the development of sarcopenia and muscle weakness, and the reduction in physical activity, is associated with decreased global DNA methylation in the peripheral blood cells of individuals aged 65–105 over a 7-year-follow-up period (Bellizzi et al. 2012). Aging is often associated with reduced levels of global DNA methylation, mostly in CpG sequences, but its physiological implications remain unclear. However, it is known that the age-related hypermethylation of the promoter regions of tumor suppressor genes increase the risk of carcinogenesis.