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Atherosclerosis, Large Arteries and Cardiovascular Disease by M.E. Safar, E.D. Frohlich, J.S. Borer

By M.E. Safar, E.D. Frohlich, J.S. Borer

Arterial stiffness is now firmly verified as a massive and self sufficient predictor of cardiovascular probability. The structural and practical adjustments of the massive arteries might be age-related, yet a couple of stipulations were linked to speeded up arterial stiffening together with the hypertensive illnesses, atherosclerosis, end-stage renal disorder, and conventional cardiovascular danger components akin to diabetes mellitus and smoking. This publication offers the present deliberating foreign specialists in regards to the underlying mechanisms of cardiovascular possibility, and the pathogenesis and pathophysiology of huge arterial stiffness and diminished huge arterial distensibility. It not just offers new insights into the connection among arterial stiffness and atherosclerosis, but additionally establishes the prospective interactions with age and different cardiovascular elements similar to hypertension, diabetes and hyperlipidemia. eventually, the healing technique of imminent arterial stiffness are analyzed intimately and new views for the remedy and prevention of cardiovascular illnesses are constructed. Authoritative and updated, this e-book is a invaluable source for uncomplicated scientists attracted to vascular body structure and pathophysiology, for clinicians within the parts of cardiology, diabetes and renal ailments, in addition to for investigators in drug improvement.

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Additional resources for Atherosclerosis, Large Arteries and Cardiovascular Disease

Example text

Safar ME: Peripheral pulse pressure, large arteries, and microvessels. Hypertension 2004; 44: 121–122. O’Rourke MF, Safar ME: Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005;46:200–204. Mitchell GF, Vita JA, Larson MG, Parise H, Keyes MJ, Warner E, Vasan RS, Levy D, Benjamin EJ: Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study.

Circulation 2002;105:2955–2961. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, Lakatta EG: Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 2001;104:1464–1470. Van Bortel LM, Spek JJ: Influence of aging on arterial compliance. J Hum Hypertens 1998; 12: 583–586. Kelly R, Hayward C, Avolio A, O’Rourke M: Noninvasive determination of age-related changes in the human arterial pulse. Circulation 1989;80:1652–1659. O’Rourke MF, Nichols WW: Changes in wave reflection with advancing age in normal subjects.

Department of Medicine, State University of New York at Buffalo 3 Gates Circle, Buffalo, NY 14209 (USA) Tel. edu Izzo /Mitchell 34 Section I – Pathophysiology Safar ME, Frohlich ED (eds): Atherosclerosis, Large Arteries and Cardiovascular Risk. Adv Cardiol. Basel, Karger, 2007, vol 44, pp 35–61 U U U U U U U U U U U U U U U U U U U U U U U U U U U Local Elasticity Imaging of Vulnerable Atherosclerotic Coronary Plaques Radj A. Baldewsing a Johannes A. W. van der Steen a, b a Biomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam, and b Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands Abstract The material composition and morphology of vulnerable atherosclerotic plaque components are considered to be more important determinants of acute coronary syndromes than the degree of stenosis.

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