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Best of Five MCQs for MRCPsych Paper 2 by Lena Palaniyappan, Rajeev Krishnadas

By Lena Palaniyappan, Rajeev Krishnadas

Following the release of the recent syllabus and new MRCPsych examination via the Royal university of Psychiatrists, this booklet comprises greater than 450 a number of selection inquiries to support psychiatry trainees to arrange for Paper 2 of the MRCPsych examination. helping those MCQs are distinct explanatory solutions and revision notes, referenced to the foremost textbooks utilized by trainees.

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Point mutations are usually substitutions, where one base is replaced by another. g. A to G). g. A to T). According to the effect on the triplet code, mutations could be a frame shift or in-frame. This leads to a shift in the triplet reading frame with variable results. In-frame mutation refers to changes occurring in multiples of three bases, with no disturbances in the reading frame. According to the effect of a mutation on the protein product, mutations could be silent, mis-sense, or nonsense.

Leonard JV and Shapira AHV. Mitochondrial respiratory chain disorders I: mitochondrial DNA defects. Lancet 2000; 355: 299–304. 33 34 PSYCHIATRIC GENETICS | ANSWERS 21. D. In testicular feminization syndrome, the karyotype is usually 46 XY. Due to insensitivity of androgen receptors, female sexual characteristics develop in such individuals. They will not have Barr bodies. In those with Kleinfelter’s syndrome, the karyotype is usually 47 XXY. Here, the individuals will have one Barr body in spite of being phenotypical males.

D. E. NRG1 BDNF G72 DISC1 DMD (Dystrophin) 75. A transcriptome refers to A. B. C. D. E. All DNA in a cell All expressed mRNA in a cell All expressed tRNA in a cell All histones in a cell All introns in a cell 76. Which of the following statements comparing the genetics of simple Mendelian disorders and schizophrenia is true? A. B. C. D. E. Schizophrenia has higher monozygotic concordance. Phenocopies are probably more common in schizophrenia than in Mendelian disorders. Locus heterogeneity within families is very common in Mendelian disorders.

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