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Cardiovascular Disease in the Elderly (Contemporary by Gary Gerstenblith

By Gary Gerstenblith

A panel of clinicians, researchers, and leaders within the box evaluation and speak about the most recent findings at the pathophysiology, analysis, and administration of heart problems within the older sufferer. The authors clarify the physiological alterations linked to the traditional getting older procedure that can bring about the improvement of ailment, to antagonistic effects as soon as ailment develops, and which adjust the risk-benefit equation for clinical and different interventions designed to diagnose, check, and deal with heart problems. the focal point is on relatively universal syndromes within the aged, together with cardiac failure with general ejection fraction, remoted systolic high blood pressure, and atrial traumatic inflammation. anyplace attainable, the authors take an evidence-based method of strategies and depend seriously on potential scientific trials.

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Ultrastructural, morphometric, and enzymatic evaluations. Arterioscler Thromb 1992;12:1008–1016. 53. Nichols WW, O’Rourke MF. Aging. In: Nichols WW, O’Rourke MF. ), McDonald’s Blood Flow in Arteries. Edward Arnold, London, 1998, pp. 378–395. 54. Sutton-Tyrrell K, Newman A, Simonsick EM, et al. Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension 2001;38:429–433. 55. Asmar R, Rudnichi A, Blacher J, London GM, Safar ME.

In fact, age has traditionally been considered a nonmodifiable risk factor. However, as noted in the preceding sections, many of the age-associated alterations in cardiovascular structure and function, at both the cellular and molecular levels, ought not to be simply considered as part of a “normal or physiological aging” process, but rather, should be construed as specific risk factors for CV diseases. This highlights the urgency to incorporate cardiovascular aging into clinical medicine, which as a requisite, will require that the following steps be implemented.

40. 41. 42. 43. 44. 45. 46. Cardiovascular Disease in the Elderly tion resistance of lipoproteins, and atherosclerotic progression. Am J Cardiol 1995; 76:34C–39C. Hodis HN, Mack WJ, LaBree L, et al. Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: a randomized controlled clinical trial. Ann Intern Med 1996;124:548–556. Markus RA, Mack WJ, Azen SP, Hodis HN. Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima-media thickness.

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