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Catecholamines by Professor Dr. H. Blaschko, F. E. Bloom, R. E. Coupland, U.

By Professor Dr. H. Blaschko, F. E. Bloom, R. E. Coupland, U. S. von Euler, R. F. Furchgott, W. Haefely, Jean Himms-Hagen, Margarethe Holzbauer, Irwin J. Kopin, H. W. Kosterlitz, G. M. Lees, E. Marley, Professor Dr. E. Muscholl, Merton Sandler, D. F. Sharman

Catecholamines 1922 -1971 H. BLASCHKO Adrenaline and similar ingredients have been mentioned within the 1924 version of Hefl'ter's guide by way of PAUL TRENDELENBURG. On 164 pages he defined what used to be then identified not just of adrenaline and its closest family members but in addition of the sympathomimetic compounds akin to tyramine and ephedrine. whilst the current Editors of the guide entrusted us with the duty of enhancing the current quantity it was once determined to limit it to adrenaline and the opposite evidently happening catecholamines. The sympathomimetic amines often may be mentioned basically of their relation to the catecholamines. when you consider that TRENDELENBURG accomplished his assessment this box has gone through an important enlargement. there was a wealth of latest findings, and a succession of recent principles. the recent theories which were equipped into modern inspiration might be absolutely mentioned within the succeeding contributions. yet some of the hypotheses which have been recommend when you consider that 1924 have lengthy been discarded and but, they've got usually resulted in very important observations that we nonetheless reflect on as valid.

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31, 2187-2196 (1937b). : Editors, Subcellular and macromolecular aspects of synaptic transmission. Phil. Trans. roy. Soc. B. 261, 273--437 (1971). - WELCH, A. : Localization of adrenaline in cytoplasmic particles of the bovine adrenal medulla. Naunyn-Schmiedeberg's Arch. expo Path. Pharmak. 219, 17-22 (1953). : Editors, Macromolecules in synaptic function. Neurosciences Res. Prog. Bull. Vol. 4, 325--455 (1970). : Benzylamine oxidase and histaminase: purification and crystallization of an enzyme from pig plasma.

Expo Ther. 117, 208-212 (1956). : Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. Brit. J. Pharmacol. 34,451-474 (1968). : Verteilung von Noradrenalin und Dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des extrapyramidalen Systems. KIin. Wschr. 15, 1236-1239 (1960). ELLIOTT, T. : On the action of adrenalin. J. Physiol. ) 31, XX-XXI (1904). : Distribution of fluorescing islets, adrenaline and noradrenaline in the adrenal medulla of the hamster.

In noradrenaline-storing cells, after glutaraldehyde-osmium tetroxide fixation, small collections of highly electron dense granular material, indicative of the presence of primary amine, have been observed within Golgi zone vesicles in both foetal and post-natal specimens (COUPLAND, 1965a; COUPLAND and WEAKLEY, 1968, 1970). In adrenaline-storing cells similar granular material fails to give electron histochemical reactions for noradrenaline. e. noradrenaline or adrenaline according to the cell type.

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