Press "Enter" to skip to content

The Comparative Biology of Aging by Norman S. Wolf

By Norman S. Wolf

Cover replica: Wolf, Norman (ed.), The Comparative Biology of Aging

The techniques of getting older and loss of life stay probably the most interesting, and mysterious, components of organic learn. large anomalies among species elevate questions the solutions to that can have primary implications for the sector of clinical technology. As scientists liberate the secrets and techniques of the quite long-lived little brown bat (up to 34 years), or the typical Budgerigar which regardless of having a metabolic cost 1.5 occasions that of a laboratory mouse, can stay for as much as two decades, it has turn into extra very important than ever in order to make a comparative research of some of the species utilized in research.

Dealing with each one of the species which are hired in laboratory learn, this is often the 1st ebook with regards to getting older that gives particular comparative information for age-related alterations in its topics. It does so on the point of the complete animal, its organs, organelles and molecules. The comparative facts, provided in 15 chapters through top specialists, offers info on fields as disparate as telomere functionality and loss, the significance of the Sirtuins and Tor, the effect of hormones on lifespans, the connection among physique measurement and lifespan, the consequences of limited calorific consumption, age-related adjustments in mobile replication, and DNA harm and service. Chapters are dedicated to cardiac getting older, comparative skeletal muscle getting older, the getting older of the fearful and immune structures, the comparative biology of lyosomal functionality and the way it's tormented by age, and plenty of different key parts of research.

This much-needed textual content will supply scientists operating in a large spectrum of fields with key information to assist them of their studies.

Show description

Read Online or Download The Comparative Biology of Aging PDF

Similar geriatrics books

Geriatrics (Health and Medical Issues Today)

Based on the U. S. Census Bureau, the speed of progress of the aged population—defined as members age sixty five or greater—increased via an element of eleven some time past century, from three million in 1900 to 33 million in 1994. in the course of the comparable period of time, the complete inhabitants in simple terms tripled. by way of the 12 months 2030, there'll be approximately seventy two million older folks, or approximately 1 in five one of the American population—more than two times their quantity in 2000.

Biological Basis of Geriatric Oncology

Organic foundation of Geriatric Oncology highlights examine matters which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and therapy, according to the biologic interactions of melanoma and age. It illustrates the advantage of the rules of geriatrics within the administration of melanoma within the older person.

Perioperative Medicine: Medical Consultation and Co-management

Presents a accomplished evidence-based consultant to the administration of the turning out to be inhabitants of sufferers who require perioperative carePerioperative medication: clinical session and Co-Management is the 1st entire reference textual content built in particular for hospitalists yet predicted additionally to assist internists, anesthesiologists, allied wellbeing and fitness pros, fellows, citizens, and scientific scholars deal with a number of features of the remedy of the surgical sufferer.

Musculoskeletal Trauma in the Elderly

Trauma in older humans elderly over sixty five is a quickly transforming into box inside of orthopaedics. as much as thirds of fractures ensue because of a fall and approximately one 3rd of all fractures happen within the over-65 inhabitants. the purpose of this complete new textual content is to provide the epidemiology and administration of all musculoskeletal trauma that happens within the aged.

Additional resources for The Comparative Biology of Aging

Sample text

Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell Oct; 6(5): 607–618. 76. Buffenstein R (2005). The naked mole-rat: A new long-living model for human aging research. J Gerontol A Biol Sci Med Sci Nov; 60(11): 1369–1377. Introduction 25 77. Salmon AB, Sadighi Akha AA, Buffenstein R, and Miller RA (2008). Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress.

Rubner M (1908). Das Problem der Lebensdauer und seine Beziehungen zum Wachstum und Ernahrung. Munich: Oldenbourg. 13. Kleiber M (1956). Energy metabolism. Annu Rev Physiol 18: 35–52. 14. McNab BK (2008). An analysis of the factors that influence the level and scaling of mammalian BMR. Comp Biochem Physiol A Mol Integr Physiol 151: 5–28. 15. Cutler RG (1979b) Evolutionary biology of senescence. )). The biology of aging. New York: Plenum Press, pp. 1–388. 16. Stahl WR (1962). Similarity and dimensional methods in biology.

J Gerontol, Biol Sci 59A: 101–107. 112. Chernoff EA, Sato K, Corn A, and Karcavich RE (2002). Spinal cord regeneration: Intrinsic properties and emerging mechanisms. Semin Cell Dev Biol Oct; 13(5): 361–368. Animal Size, Metabolic Rate, and Survival, Among and Within Species Steven N. Austad Abstract The positive interspecific relation between mammalian body size and longevity was described more than a century ago and remains one of the most robust patterns known in the biology of aging. Hypotheses about the role of metabolic rate or relative brain size in explaining this pattern have not been supported by detailed analyses.

Download PDF sample

Rated 4.47 of 5 – based on 27 votes