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Extra info for Deutsche Gesellschaft für Pharmakologie und Toxikologie: Abstracts of the Autumn Meeting 10–14 September 1991, Berlin

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Indeed, we have recently shown that removal of basal NO synthesis in aortic rings, either by endothelium removal or by inhibition of NO synthesis, leads to a supersensitivity to nitrovasodilators at the level of their receptor, the soluble guanylate cyclase (13). It is tempting to speculate that this mechanism may account for the effectiveness of these compounds in angina where a reduced synthesis of NO by the coronary vascular endothelium, and the consequent up-regulation of their receptor, may confer some selectivity of nitrovasodilators on this vascular bed.

1990). , lli: 87-90. 17. L. and Moncada S. (1990). Biochem. Biophys. Res. , ill: 1042-1048. 18. B. J. R. Jr. (1990). In: Nitric oxide from L-arginine. A bioregulatory system. ed. Moncada S. A. 189-223. Elsevier. 19. Vallance P. and Moncada S (1991). Lancet, m: 776-778. 20. , Carnuccio R. and Moncada S. (1990). Biochem. Biophys. Res. , 172: 1246-1252. 21. J. and Moncada S. (1987). Br. J. , 22: 181-187. 22. J. and Moncada S. (1987). Biochem. Biophys. Res. , ill: 1482-1489. 23. J. and Moncada S. (1990).

When GC-A is expressed in various cultured mammalian cells, high expression of both atrial natriuretic peptide (ANP) binding and guanylyl cyclase activity are observed. Radiolabeled ANP also can be specHically crosslinked to the expressed protein. It is also possible to express GC-A in insect cells (Sf-9), and under these condttions both high ANP binding activity and guanylyl cyclase activity also are obtained. From these and other studies, tt is apparent that GC-A serves as an ANP cell surface receptor.

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