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Clinical Research in Complementary Therapies: Principles, by George Thomas Lewith MA DM FRCP MRCGP, Wayne B. Jonas MD,

By George Thomas Lewith MA DM FRCP MRCGP, Wayne B. Jonas MD, Harald Walach Dip Psych PhD

There's a massive and lengthening curiosity in examine regarding complementary cures to set up a base of study effects to be able to help perform. even though, no longer all treatments may be handled a similar approach, both from a similar standpoint of what overall healthiness and remedy are, or channelled in the course of the strategy of randomized, managed trials. This booklet analyzes the most important questions frequently requested and the controversies debated in complementary medication learn, and provides transparent suggestions written by means of specialists during this box.

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Symposion Publishing, DUsseldorf, pp 27-40 42 METHODS AND STRATEGIES Antonuccio DO, Danton WG, DeNelsky GY, Greenberg RP,Gordon JS 1999 Raising questions about antidepressants. Psychotherapy and Psychosomatics 68: 3-14 Arnkoff DB, Victor BI, Glass CR 1993 Empirical research on factors in psychotherapeutic change. In: Stricker G, Gold JR (eds) Comprehensive handbook of psychotherapy integration. Plenum, New York, pp 27-42 Black N 1996 Why we need observational studies to evaluate the effectiveness of health care.

Typically, in CAM we have a whole array of possible interventions or strategies for a given disease, which in most cases are applied with detailed individualization. This application is usually based on a disease assessment and classification different from those usually selected for homogeneity in clinical trials. For instance, in classical homeopathy, the target of treatment is not the nosological or diagnostic entity but a set of complex characteristics of the patient and all of their symptoms.

Publication bias is considerable, since funding often comes from the pharmaceutical industry which has the power to suppress unwanted results (Antonuccio et al 1999,Dickersin & Min 1993, Dickersin et aI1987). Thus, evidence synthesized in metaanalyses and systematic reviews may be positively biased. Learning from psychotherapy research Psychotherapy research (PTR) can serve as a good example. Few would challenge the overall effectiveness of psychotherapy (PT), although a number of problems remain to be resolved (Garfield & Bergin 1986, Grawe et aI1994).

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